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How two telomere proteins interact with each other and the functional effects...
Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeres—the ends of our chromosomes. The study, published online in Nature Communications, explains how a...
View ArticleMaternal stress during pregnancy could influence the biological clock for ageing
The stress that some mothers experience during their pregnancies could influence the genetic makeup their babies are born with and, eventually, lead to premature biological ageing and associated...
View ArticleNew test more effective at predicting survival in blood cancer patients
Technology that can detect the length of small DNA structures in cancer cells could hold the key to predicting the outcome of patients with two different types of blood cancer. The test, used in...
View ArticleHigh levels of exercise linked to nine years of less aging at the cellular level
Despite their best efforts, no scientist has ever come close to stopping humans from aging. Even anti-aging creams can't stop Old Father Time.
View ArticleA more detailed understanding of cell divisions giving rise to sperm and egg...
Researchers have shown that a recently identified protein, called Speedy A, plays an essential role in the early stages of meiosis—a special type of cell division that produces sperm and egg cells.
View ArticleStudy shows telomere shortening in youth with higher pollution exposure
Children and teens exposed to high levels of traffic-related air pollution have evidence of a specific type of DNA damage called telomere shortening, reports a study in the May Journal of Occupational...
View ArticleDiscovery improves understanding of cellular aging and cancer development
A team of researchers led by Dr Dennis Kappei, a Special Fellow from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), has discovered the role of...
View ArticleBoozing can age you right down to your cells
(HealthDay)—The more you booze it up, the more your cells age, increasing your risk for age-related health problems like heart disease, diabetes, cancer and dementia, a new study suggests.
View ArticleStudy of premature babies has implications for future treatment
Research carried out by the University with doctors on the neonatal unit at the William Harvey Hospital and Brunel University have provided further insight into the biology of premature birth, with...
View ArticleAt the cellular level, a child's loss of a father is associated with...
The absence of a father—due to incarceration, death, separation or divorce—has adverse physical and behavioral consequences for a growing child. But little is known about the biological processes that...
View ArticlePotential biomarker discovered to allow more precise classification of...
After leukaemia, primary tumours of the brain and spinal cord are the second commonest cancers in childhood and adolescence. The presence of the enzyme telomerase characterises a particularly malignant...
View ArticleRisk for bipolar disorder associated with faster aging
New King's College London research suggests that people with a family history of bipolar disorder may 'age' more rapidly than those without a history of the disease.
View ArticleCRISPR sheds light on rare pediatric bone marrow failure syndrome
Using the gene editing technology CRISPR, scientists have shed light on a rare, sometimes fatal syndrome that causes children to gradually lose the ability to manufacture vital blood cells.
View ArticleResearchers develop technology to make aged cells younger
Aging. We all face it. Nobody's immune and we've long tried to reverse it, stop it or just even slow it down. While advances have been made, true age-reversal at a cellular level remains difficult to...
View ArticleStress in the nest can have lifelong effect
Why do some sparrows hatch six chicks while others don't hatch any? How does upbringing affect the remainder of their lives? Physiological stress in the nest can actually affect birds' DNA and possibly...
View ArticleTwo-step process leads to cell immortalization and cancer
A mutation that helps make cells immortal is critical to the development of a tumor, but new research at the University of California, Berkeley suggests that becoming immortal is a more complicated...
View ArticleTelomere length prognostic in hepatocellular carcinoma
(HealthDay)—Telomere attrition occurs in tumor cells from patients with hepatocellular carcinoma (HCC), and shortened telomeres are independent prognosticators for HCC patients, according to a study...
View ArticleTeam finds that telomere length can have a direct correlation to heart...
Each cell in the average human body contains 23 pairs of chromosomes, with four telomeres on each pair. Telomeres cover the end of the chromosome, protecting it from deterioration or fusion with...
View ArticleResearchers find shortened telomeres linked to dysfunction in Duchenne...
Researchers from the Perelman School of Medicine at the University of Pennsylvania have made a discovery about muscular dystrophy disorders that suggest new possibilities for treatment. In a study...
View ArticleChildhood poverty, poor support may drive up pregnant woman's biological age
Pregnant women who had low socioeconomic status during childhood and who have poor family social support appear to prematurely age on a cellular level, potentially raising the risk for complications, a...
View ArticleResearchers connect two important signalling pathways in cancer and ageing...
The structure of proteins that protect telomeres (shelterin proteins, from "protective shield") are promising targets to combat cancer, but to date, there has been no effective form for attacking them....
View ArticleSugary drinks linked to reduced DNA protection in Latino preschoolers
Consumption of sugar-sweetened beverages by children between 2 and 3 years of age has been linked to shorter telomeres in a new, preliminary study by researchers from UC San Francisco. The study raises...
View ArticleNew assay may help predict which pancreatic lesions may become cancerous
A report in The Journal of Molecular Diagnostics, describes a new simple molecular test to detect chromosomal abnormalities—biomarkers known as telomere fusions—in pancreatic tumor specimens and...
View ArticleCancer therapies may trigger aging phenotypes in survivors
(HealthDay)—Cancer therapies have direct effects on telomere length, epigenetic modifications, and microRNA, which can mimic phenotypes of aging, according to a review published online Dec. 18 in ESMO...
View ArticleWhen a mom feels depressed, her baby's cells might feel it too
An estimated 1 in 9 women experience symptoms of postpartum depression. These symptoms – including mood swings, fatigue and reduced interest in activities – can make it difficult for mothers to bond...
View ArticleScientists find mechanisms to avoid telomere instability found in cancer and...
Researchers from Instituto de Medicina Molecular (iMM) João Lobo Antunes have found that a functional component of telomeres called TERRA has to be kept constantly in check to prevent telomeric and...
View ArticleAir pollution may shorten telomeres in newborns
A study conducted before and after the 2004 closure of a coal-burning power plant in Tongliang, China, found children born before the closure had shorter telomeres than those conceived and born after...
View ArticleResearchers cure lung fibrosis in mice with a gene therapy that lengthens...
Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment. The Telomere and Telomerase Group at the...
View ArticleLong-term consumption of sunflower and fish oils damages the liver
An international group of scientists led by the University of Granada (UGR) has demonstrated that the long-term intake of sunflower or fish oils damages the liver and can give rise to non-alcoholic...
View ArticleGenome wide association study of epigenetic aging rates in blood reveals a...
Researchers from several institutions, including, UCLA, Boston University, Stanford University and the Institute for Aging Research at Hebrew SeniorLife, analyzed blood samples from nearly 10,000...
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